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KMID : 0370220170610040222
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Yakhak Hoeji
2017 Volume.61 No. 4 p.222 ~ p.226
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Formation of Novel Alkylsulfonyl Group Substituted Dipyridazinyl Diselenides by Diselenylation
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Kim Chae-Won
Park Myung-Sook
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Abstract
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A new series of bis (pyridazinyl) diselenides was synthesized by diselenylation from pyridazinyl chloride for search of antiproliferative agents. The process involves the alkylthiolation, oxidation (sulfonylation and sulfinylation) and diselenylation from 3,6-dichloropyridazine. The alkylsulfonyl (or sulfinyl) pyridazinyl chloride (3c, 4a~4f) could be converted to target diorganodiselenides 5c, and 6a~6f with selenium, hydrazine hydrate under atmospheric pressure in the presence of sodium hydroxide. The structures of the synthetic compounds were characterized using 1H and 13C NMR spectroscopy.
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KEYWORD
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Diaryl diselenides, Organoseleniums, Bis(alkylsulfonylpyridazinyl) diselenides, Diorganodiselenides, Diselenylation
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